Stockholm, Jul 7 (IANS): Swedish scientists have developed a new method that detects the efficiency of drug molecules in reaching their targets, says a study.

The method, which is described in the scientific journal Science, could make a significant contribution to the development of new, improved drug substances, reports Science Daily.

Most drugs operate by binding to one or more proteins and affecting their function, which creates two common bottlenecks in the development of drugs -- identifying the right target proteins and designing drug molecules able to efficiently seek out and bind to them.

Until now, no method was available for directly measuring the efficiency of the drug molecules to locate and bind to their target protein.

Researchers from Karolinska Institutet have developed a new tool called CETSA (Cellular Thermal Shift Assay), which utilises the concept that target proteins usually get stabilised when drug molecules bind.

"We have shown that the method works on a wide variety of target proteins and allows us to directly measure whether the drug molecules reach their targets in cells and animal models," says lead investigator Professor Par Nordlund of the department of medical biochemistry and biophysics at Karolinska Institutet in Sweden.

"We believe that CETSA will eventually help to improve the efficiency of many drugs and contribute to better drug molecules and more successful treatments," Nordlund said.